Antibiofilm Effect of D-enantiomeric Peptide Alone and Combined with EDTA In Vitro.
Identifieur interne : 000E86 ( Main/Exploration ); précédent : 000E85; suivant : 000E87Antibiofilm Effect of D-enantiomeric Peptide Alone and Combined with EDTA In Vitro.
Auteurs : Dan Wang [Canada] ; Ya Shen [Canada] ; Jingzhi Ma [République populaire de Chine] ; Robert E W. Hancock [Canada] ; Markus Haapasalo [Canada]Source :
- Journal of endodontics [ 1878-3554 ] ; 2017.
Descripteurs français
- KwdFr :
- Acide édétique (administration et posologie), Acide édétique (pharmacologie), Antibactériens (pharmacologie), Association de médicaments (MeSH), Biofilms (effets des médicaments et des substances chimiques), Enterococcus faecalis (effets des médicaments et des substances chimiques), Microscopie confocale (MeSH), Oligopeptides (pharmacologie), Techniques in vitro (MeSH).
- MESH :
- administration et posologie : Acide édétique.
- effets des médicaments et des substances chimiques : Biofilms, Enterococcus faecalis.
- pharmacologie : Acide édétique, Antibactériens, Oligopeptides.
- Association de médicaments, Microscopie confocale, Techniques in vitro.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Edetic Acid.
- chemical , pharmacology : Anti-Bacterial Agents, Edetic Acid, Oligopeptides.
- drug effects : Biofilms, Enterococcus faecalis.
- Drug Therapy, Combination, In Vitro Techniques, Microscopy, Confocal.
Abstract
INTRODUCTION
The aim of this study was to evaluate the effect of DJK-5, a newly developed cationic antimicrobial peptide, on oral multispecies and Enterococcus faecalis biofilms alone or combined with the endodontic chelating agent EDTA in vitro.
METHODS
Oral multispecies biofilms from 2 donors and E. faecalis VP3-181 biofilm were grown on collagen-coated hydroxyapatite disks. After incubation for 3 days or 3 weeks, the biofilms were exposed to sterile saline (negative control), 8.5% EDTA, 2% chlorhexidine digluconate (CHX), 5 μg/mL DJK-5, 10 μg/mL DJK-5, a mixture of 5 μg/mL DJK-5 and 8.5% EDTA (final concentration), or a mixture of 10 μg/mL DJK-5 and 8.5% EDTA, all for 1 and 3 minutes. The proportions of dead bacteria in the biofilms were assessed by the LIVE/DEAD staining (Thermo Fisher Scientific, Waltham, MA) and confocal microscopy.
RESULTS
The peptide DJK-5 rapidly killed most bacteria in all biofilms, with significant differences to the control, 8.5% EDTA and 2% CHX (P < .01). Basically, a higher DJK-5 concentration and longer exposure (3 minutes) were more effective than a low concentration and short time exposure (P < .05). There were no significant differences in antibiofilm activities between DJK-5 used alone or in the mixture with 8.5% EDTA at either concentration. EDTA (8.5%) had no significant antimicrobial effect compared with the negative control (P > .05), but, unlike DJK-5 alone, the mixture retained the ability to remove smear layers. In peptide groups, there were no significant differences in dead bacteria proportions between 3-day and 3-week biofilms, except for 10 μg/mL DJK-5 used alone for 3 minutes on the multispecies biofilms.
CONCLUSIONS
DJK-5 exerted antibiofilm ability on E. faecalis and oral multispecies biofilms grown on hydroxyapatite disks, both alone and when combined with 8.5% EDTA.
DOI: 10.1016/j.joen.2017.06.037
PubMed: 28951034
Affiliations:
- Canada, République populaire de Chine
- Colombie-Britannique , Hubei
- Vancouver, Wuhan
- Université de la Colombie-Britannique
Links toward previous steps (curation, corpus...)
Le document en format XML
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<term>Edetic Acid (administration & dosage)</term>
<term>Edetic Acid (pharmacology)</term>
<term>Enterococcus faecalis (drug effects)</term>
<term>In Vitro Techniques (MeSH)</term>
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<term>Acide édétique (pharmacologie)</term>
<term>Antibactériens (pharmacologie)</term>
<term>Association de médicaments (MeSH)</term>
<term>Biofilms (effets des médicaments et des substances chimiques)</term>
<term>Enterococcus faecalis (effets des médicaments et des substances chimiques)</term>
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<term>Oligopeptides (pharmacologie)</term>
<term>Techniques in vitro (MeSH)</term>
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<front><div type="abstract" xml:lang="en"><p><b>INTRODUCTION</b>
</p>
<p>The aim of this study was to evaluate the effect of DJK-5, a newly developed cationic antimicrobial peptide, on oral multispecies and Enterococcus faecalis biofilms alone or combined with the endodontic chelating agent EDTA in vitro.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Oral multispecies biofilms from 2 donors and E. faecalis VP3-181 biofilm were grown on collagen-coated hydroxyapatite disks. After incubation for 3 days or 3 weeks, the biofilms were exposed to sterile saline (negative control), 8.5% EDTA, 2% chlorhexidine digluconate (CHX), 5 μg/mL DJK-5, 10 μg/mL DJK-5, a mixture of 5 μg/mL DJK-5 and 8.5% EDTA (final concentration), or a mixture of 10 μg/mL DJK-5 and 8.5% EDTA, all for 1 and 3 minutes. The proportions of dead bacteria in the biofilms were assessed by the LIVE/DEAD staining (Thermo Fisher Scientific, Waltham, MA) and confocal microscopy.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>The peptide DJK-5 rapidly killed most bacteria in all biofilms, with significant differences to the control, 8.5% EDTA and 2% CHX (P < .01). Basically, a higher DJK-5 concentration and longer exposure (3 minutes) were more effective than a low concentration and short time exposure (P < .05). There were no significant differences in antibiofilm activities between DJK-5 used alone or in the mixture with 8.5% EDTA at either concentration. EDTA (8.5%) had no significant antimicrobial effect compared with the negative control (P > .05), but, unlike DJK-5 alone, the mixture retained the ability to remove smear layers. In peptide groups, there were no significant differences in dead bacteria proportions between 3-day and 3-week biofilms, except for 10 μg/mL DJK-5 used alone for 3 minutes on the multispecies biofilms.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>DJK-5 exerted antibiofilm ability on E. faecalis and oral multispecies biofilms grown on hydroxyapatite disks, both alone and when combined with 8.5% EDTA.</p>
</div>
</front>
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<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">The aim of this study was to evaluate the effect of DJK-5, a newly developed cationic antimicrobial peptide, on oral multispecies and Enterococcus faecalis biofilms alone or combined with the endodontic chelating agent EDTA in vitro.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Oral multispecies biofilms from 2 donors and E. faecalis VP3-181 biofilm were grown on collagen-coated hydroxyapatite disks. After incubation for 3 days or 3 weeks, the biofilms were exposed to sterile saline (negative control), 8.5% EDTA, 2% chlorhexidine digluconate (CHX), 5 μg/mL DJK-5, 10 μg/mL DJK-5, a mixture of 5 μg/mL DJK-5 and 8.5% EDTA (final concentration), or a mixture of 10 μg/mL DJK-5 and 8.5% EDTA, all for 1 and 3 minutes. The proportions of dead bacteria in the biofilms were assessed by the LIVE/DEAD staining (Thermo Fisher Scientific, Waltham, MA) and confocal microscopy.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The peptide DJK-5 rapidly killed most bacteria in all biofilms, with significant differences to the control, 8.5% EDTA and 2% CHX (P < .01). Basically, a higher DJK-5 concentration and longer exposure (3 minutes) were more effective than a low concentration and short time exposure (P < .05). There were no significant differences in antibiofilm activities between DJK-5 used alone or in the mixture with 8.5% EDTA at either concentration. EDTA (8.5%) had no significant antimicrobial effect compared with the negative control (P > .05), but, unlike DJK-5 alone, the mixture retained the ability to remove smear layers. In peptide groups, there were no significant differences in dead bacteria proportions between 3-day and 3-week biofilms, except for 10 μg/mL DJK-5 used alone for 3 minutes on the multispecies biofilms.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">DJK-5 exerted antibiofilm ability on E. faecalis and oral multispecies biofilms grown on hydroxyapatite disks, both alone and when combined with 8.5% EDTA.</AbstractText>
<CopyrightInformation>Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Dan</ForeName>
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<AffiliationInfo><Affiliation>Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Faculty of Dentistry, Division of Endodontics, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.</Affiliation>
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</AffiliationInfo>
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<affiliations><list><country><li>Canada</li>
<li>République populaire de Chine</li>
</country>
<region><li>Colombie-Britannique </li>
<li>Hubei</li>
</region>
<settlement><li>Vancouver</li>
<li>Wuhan</li>
</settlement>
<orgName><li>Université de la Colombie-Britannique</li>
</orgName>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Wang, Dan" sort="Wang, Dan" uniqKey="Wang D" first="Dan" last="Wang">Dan Wang</name>
</noRegion>
<name sortKey="Haapasalo, Markus" sort="Haapasalo, Markus" uniqKey="Haapasalo M" first="Markus" last="Haapasalo">Markus Haapasalo</name>
<name sortKey="Hancock, Robert E W" sort="Hancock, Robert E W" uniqKey="Hancock R" first="Robert E W" last="Hancock">Robert E W. Hancock</name>
<name sortKey="Shen, Ya" sort="Shen, Ya" uniqKey="Shen Y" first="Ya" last="Shen">Ya Shen</name>
</country>
<country name="République populaire de Chine"><region name="Hubei"><name sortKey="Ma, Jingzhi" sort="Ma, Jingzhi" uniqKey="Ma J" first="Jingzhi" last="Ma">Jingzhi Ma</name>
</region>
</country>
</tree>
</affiliations>
</record>
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